What goes wrongSurface curing (a skin forming on the top of the coat while the body remains wet) was observed by the OP when the furo was set above 80 % RH. The OP attributed it to the surface drying faster than the interior and backed the humidity down. A related concern raised by the OP is that laccase activity may decline after several hours of open exposure, though no visible defect was reported.
What recovers itIf surface skin appears, lower the relative humidity or raise the temperature so the absolute moisture gradient across the film is gentler. For open-time anxiety on large panels, the practical mitigation the OP already uses—mixing only enough for one face at a time and topping up with fresh urushi plus a little turpentine before finishing the panel—was endorsed as workable.